Description

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene.

References
1.Blood. 2015 Sep 17;126(12):1443-51. 2.Cytometry B Clin Cytom. 2012 May;82(3):145-50.

Specification
Aliases	CD8; p32; Leu2
Entrez GeneID	925
Swissprot	P01732
clone	7H4B10
WB Predicted band size	25.7kDa
Host/Isotype	Mouse IgG1
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant fragment of human CD8a (AA: 22–235) expressed in E. Coli.
Formulation	Purified antibody in PBS with 0.05% sodium azide

Application
FCM	1/200 - 1/400
ELISA	1/10000