Description

S100B (S100 calcium binding protein B) is a member of the S100 family of proteins containing 2 EF-hand calcium binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S-100 proteins and parvalbumin proteins are each expressed in neural tissues. In addition, S100B are present in a variety of other tissues, and calbindin is present in intestine and kidney. Parvalbumin B is found in many tumor tissues as well as in the organ of Corti. Calbindin, S-100 proteins and parvalbulmins have all been detected in leydig cells and the testis. These proteins are thought to play a role in hormone production and spermatogenesis. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.

References
1. Shapiro LA. Marks A. Whitaker-Azmitia PM. Brain Res. 2004, Jun 4,1010(1-2):17-21. 2. Sorci G. Riuzzi F. Arcuri C. et al. Mol Cell Biol. 2004, Jun,24(11):4880-94. 3. Zimmer DB. Chaplin J. Baldwin A. et al. Cell Mol Biol (Noisy-le-grand).2005,Sep 5,51(2):201-14.

Specification
Aliases	NEF; S100; S100beta
Entrez GeneID	6285
Swissprot	P04271
clone	9A11B9
Host/Isotype	Mouse IgG1
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant fragment of S100B expressed in E. Coli.
Formulation	Ascitic fluid containing 0.03% sodium azide.

Application
IHC	1/200 - 1/1000
ELISA	1/10000