Description

CD20 (MS4A1, membrane-spanning 4-domains, subfamily A, member 1) is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. The CD20 antigen is present on human pre B lymphocytes and on B lymphocytes at all stages of maturation, except on plasma cells. Low level expression of the CD20 antigen has been detected on normal T lymphocytes. The CD20 molecule is involved in regulation of B cell differentiation, presumably via its reported function as a Ca++ channel subunit. And it is known to accelerate the G0 to G1 progression induced by IGF-1.

References
1. Byar K. Semin Oncol Nurs. 2004,Feb, 20 (1 Suppl 1):20-5. Review. 2. Reiners KS. Hansen HP. Kr

Specification
Aliases	B1; S7; Bp35; CD20; MS4A2; LEU-16; MGC3969; MS4A1
Entrez GeneID	931
Swissprot	P11836
clone	3E9D3C1G3
Host/Isotype	Mouse IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthetic peptide corresponding to aa (EPANPSEKNSPSTQY) of human CD20,conjugated to KLH.
Formulation	Ascitic fluid containing 0.03% sodium azide.

Application
IHC	1/200 - 1/1000
ICC	1/200 - 1/1000
ELISA	1/10000