Description

FES (feline sarcoma oncogene) and Fer are the only two members of a unique family of cytoplasmic protein tyrosine kinases. FES and Fer contain a central Src homology-2 (SH2) domain and a carboxy-terminal tyrosine kinase catalytic domain. They are structurally distinguished from other members of cytoplasmic protein tyrosine kinase subfamilies by the presence of amino-terminal Fer/CIP4 homology and coiled-coil domains. FES was originally identified as an oncogene from avian and feline retroviruses. Human c-Fes has been implicated in myeloid, vascular endothelial and neuronal cell differentiation. FES has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Mutations may activate the FES kinase and thereby contribute to cancer. However, recent data strongly suggests that the c-FES protein-tyrosine kinase is a tumor suppressor rather than a dominant oncogene in colorectal cancer.

References
1. Delfino FJ. Stevenson H. Smithgall TE. J Biol Chem. 2006, Mar 31, 281(13): 8829-35. Epub 2006 Feb 2. 2. Durfee WK. Rivard A. J Biomech Eng. 2005, Nov, 127(6):1014-9. 3. Vitenzon AS. Mironov EM. Petrushanskaya KA. Neurosci Behav Physiol. 2005, Sep, 35(7):709-14.

Specification
Aliases	FPS
Entrez GeneID	2242
Swissprot	P07332
clone	2E3G3
Host/Isotype	Mouse IgG1
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Purified recombinant fragment of FES (AA:613-822)expressed in E. Coli.
Formulation	Ascitic fluid containing 0.03% sodium azide.

Application
IHC	1/200 - 1/1000
ELISA	1/10000