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Immunohistochemical analysis of paraffin-embedded human breast intraductal carcinama tissue(A) and breast infiltrating ductal carcinama tissue(B) showing membrane localization using HER-2 mouse mAb with DAB staining.

Mouse Monoclonal Antibody to HER-2

  • 货号:

    20127
  • 别名:

    HER-2, C-erB-2, erbB-2
  • 应用:

    IHC
  • 反应种属:

    Human
  • 规格:

  • 数量:

    -
    +
  • 说明书:

    目录价¥2180

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Mouse Monoclonal Antibody to HER-2

Description
The C-erbB-2 (HER-2/neu) gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. Amplification or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. High levels of c-erbB-2 were associated with estrogen receptor (ER) and progesterone receptor negativity. Overexpression of the c-erbB-2 oncogene has been shown to be associated with poor prognosis in ovarian and breast cance, The level of increased Neu expression can be a predictor of disease prognosis
References
1. RR Mehta, JH McDermott, TJ Hieken, et al. J. Clin. Oncol. 1998;16:2409 - 2416.
2. Hideko Y, Vered S, and Daniel F.H, et al. J. Clin. Oncol.2001;19:2334 - 2356.
3. Magali F, Kamel H, C
Specification
Aliases HER-2, C-erB-2, erbB-2
Entrez GeneID 2064
Swissprot P04626
clone 9B9D8
Host/Isotype Mouse IgG2b
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of HER-2 expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Application
IHC 1/200 - 1/1000
ELISA 1/10000

For Reseach Only

Application Key:WB - Western Blot | IHC - Immunohistochemistry | ICC - Immunocytochemistry | FCM - Flow Cytometry | ELISA - Enzyme-linked Immunosorbent Assay | IP - Immunoprecipitation

#20127